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Objective: To propose reasonable suggestions to promote the standardization of clinical studies by reviewing the systematic reviews and meta-analyses of acupuncture-moxibustion treatment of essential hypertension (EH). Methods: Computer retrieval was conducted through Excerpta Medica Database (EMBASE), PubMed, China National Knowledge Infrastructure (CNKI), Chongqing VIP Database (CQVIP), China Biology Medicine Disc (CBM), and Wanfang Academic Journal Full-text Database (Wanfang) to collect systematic reviews and meta-analyses relevant to treating EH with acupuncture-moxibustion therapy. The time range was from the database's inception till July, 2020. The studies were screened based on the inclusion and exclusion criteria and then data-extracted. The study's quality and evidence ratings were performed by referring to the preferred reporting items for systematic review and meta-analysis (PRISMA), a measurement tool to assess systematic reviews 2 (AMSTAR 2), and the grading of recommendations, assessment, development, and evaluation (GRADE). Results: A total of 14 studies, 10 in Chinese and 4 in English, published between 2012 and 2019, were included, involving 70 outcome measures. The methodological quality was rated as critically low, the reporting was relatively complete or had certain flaws, and the evidence strength was rated as low or very low. Conclusion: Regarding the acupuncture-moxibustion treatment of EH, the methodological quality and outcome measure evidence of existing systematic reviews and meta-analyses are relatively low, and the reporting quality also expects further improvements.
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Objective:To investigate the expressions of microRNA-26b (miR-26b) and microRNA-1 (miR-1) in serum of elderly patients with stroke depression and their relationships with prognosis.Methods:148 elderly stroke patients treated in Hubei Provincial Hospital of Traditional Chinese Medicine from March 2017 to February 2018 were divided into simple stroke group [60 cases, Hamilton Depression Scale (HAMD) score <7 points] and stroke depression group (88 cases, HAMD score ≥7 points). Real-time fluorescence quantitative polymerase chain reaction (qRT-PCR) was used to detect the levels of microRNA-26b and microRNA-1 in the serum of all subjects; the relationships between the expressions of microRNA-26b and microRNA-1 and clinical parameters were analyzed, the relationship between the expressions of microRNA-26b and microRNA-1 and the prognosis of patients were analyzed; Logistic regression was used to analyze the prognostic factors of depression in stroke patients.Results:The expression of microRNA-26b in serum of patients in stroke depression group was significantly lower than that of patients in simple stroke group, and the expression of miR-1 was significantly higher than that of patients in simple stroke group ( P<0.05). The HAMD scores of patients with low expression of microRNA-26b and the high expression of miR-1 were significantly higher than those of patients with high expression of microRNA-26b and the low expression of miR-1 ( P<0.05). Pearson analysis showed that there was a significant negative correlation between microRNA-26b and HAMD score ( r=-0.364, P<0.01), and a significant positive correlation between miR-1 and HAMD score ( r=0.392, P<0.01). In the stroke depression patients with different prognosis, the HAMD score and the expression of miR-1 in the cured group were significantly lower than those in the non-cured group, and the expression of microRNA-26b was significantly higher than that in the non-cured group ( P<0.05). Logistic regression analysis showed that HAMD and miR-1 were the risk factors of poor prognosis in patients with stroke depression, and miR-26b was the protective factor of poor prognosis in patients with stroke depression. Conclusions:The levels of serum miR-1 and mir-26b were increased and decreased in elderly patients with stroke depression. Both of them were related to the prognosis of patients and were the influencing factors of adverse prognosis in patients with stroke depression.
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Astract:Objective To compare the clinical efficacy of minimally invasive percutaneous osteosynthesis and supercutaneous plating with closed reduction in the treatment of distal tibial comminuted fractures. Methods A total of 40 patients with close distal tibial comminuted fractures in our hospital from April 2012 to April 2014 were divided into minimally invasive percutaneous osteosynthesis group and external fixation group. External fixation group were treated by supercutaneous plating,while the minimally invasive percutaneous osteosynthesis group were treated by minimally invasive percutaneous osteosynthesis. And the operative duration,hospital stay,the time of weight loading and frac-ture healing,postoperative complications and function of ankle were compared between the two groups. Results In the supercutaneous plating group,the operative duration was (60. 17 ± 5. 64) minutes,the hospital stay was (8. 651 ± 2. 21) days,the time of weight loading was (49.26 ±9.85)days,the time of fracture healing was (13.82 ±4.23)weeks,the incidence of postoperative complications was 5.00%,and the excellent and good rates was 95. 00%. In the minimally invasive percutaneous osteosynthesis group,the operative duration was (74. 64 ± 6. 82)minutes,the hospital stay was (18. 22 ± 2. 32)days,the time of weight loading was (57. 56 ± 11. 32)days,the time of fracture healing was (17. 47 ± 2. 31)weeks,the incidence of postoperative complications was 25. 00%,and the excellent and good rates was 80. 00%. There were significant differences in operative duration(χ2 =9. 922,P=0. 007),hospital stay(χ2 =10. 48,P=0. 015),time of weight loading (χ2 =14. 618,P=0. 001) and fracture healing(χ2 =40. 16,P=0. 000) between the two groups. The AOFSA score of supercutaneous plating group was (89. 1 ± 3. 9)point,compared with (90. 5 ± 4. 1)point of minimally invasive percutaneous osteosynthesis group,and the difference was statistically significant(χ2 =0. 463,P=0. 793). Conclusion Distal tibial fractures may be treated successfully with minimally invasive plate osteosynthesis or supercutaneous plating. However,supercutaneous plating offers multiple advantages in terms of mean operative dura-tion,hospital stay,the time of weight loading and fracture healing.
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Objective: To make a system evaluation on the therapeutic effect and safety of Mailuoning Injection(MI) in treating acute stage of ischemic brain infarction apoplexy(IBIA).Methods: Literatures about randomized controlled trial (RTC) on MI in treating acute stage of IBIA were collected,and the qualified researches were filtrated.Then made a quality evaluation by Jadad scoring method, and took statistics of the correlated data with the methods of heterogeneity test,Meta-analysis,filler-graph analysis and sensitivity analysis etc.Results: There were eight items accorded with bringing into standard.Then the methodology quality of each articles were evaluated adopting Jadad scoring standard,and the trials each get one score,belonging to low-quality literatures.The analytic results of Meta-analysis showed that compared with blank control group,the total effective rate comparison relative risk(RR) to merge equaled 1.19,99% confidence interval(CI) was(1.09,1.30),the case-fatality rate(CFR) comparison relative risk(RR) equaled 0.93,99% confidence interval(CI) was(0.02,36.07). Conclusion: This system evaluation demonstrated that MI was good for treating acute stage of IBIA,and no serious adverse reactions.